ANTIPHOSPOLIPID ANTIBODY SYNDROME
INTRODUCTION:-
Antiphospholipid Syndrome (APS , APLS), also known as Antiphospholipid antibody syndrome or ‘Sticky blood Syndrome’or Hughes syndrome is a disorder characterized by elevated level of multiple different antibodies that are associated with arterial and venous thrombosis and pregnancy related complications. This syndrome occurs due to auto antibodies against phospholipids (aPL), a cell membrane substances. The antibodies are found against cardiolipin (anticardiolipin antibodies) and ?2 glycoprotein I (?2 GP1).
These aPL antibodies were first seen in some patients with positive test for syphilis without infection out of which few developed SLE(Systemic Lupus Erythematosus ) and other similar conditions. Later lupus anticoagulant was detected in few cases of SLE. A case report in 1956 showed repeated pregnancy loss,thrombophlebitis and lupus anticoagulant. In 1980 the rheumatologist Dr. Graham R. V. Hughes of St. Thomas’ Hospital , London provided the details including the test for anticardiolipin antibodies. Later anticardiolipin antibodies were found to act against ?2GP1,while lupus anticoagulant was found to act against ?2GP1 and more recently prothrombin.
Gandhi Medical College,Padmarao Nagar, Secunderabad
Gandhi Medical College, founded 14 September 1954, is a medical college in Padmarao Nagar, Secunderabad in the state of Andhra Pradesh, India.
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Andhra Medical College,Visakhapatnam, Andhra Pradesh
Andhra Medical College is one of the premier medical colleges in Visakhapatnam, Andhra Pradesh, India. It is affiliated to NTR University of Health Sciences.
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Basic sciences
Basic sciences
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Medical Colleges
A medical College is a tertiary educational institution—or part of such an institution—that teaches medicine. In addition to a medical degree program, some medical schools offer programs leading to a Master's Degree, Doctor of Philosophy (PhD), Doctor of Medicine (MD), or other post-secondary education.



